KMID : 0613820170270080888
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Journal of Life Science 2017 Volume.27 No. 8 p.888 ~ p.895
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Anti-obesity Effect of Salsola collina Ethanol Extract
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Jin Kyong-Suk
Lee Su-Hyeon Kwon Hyun-Ju Kim Byung-Woo
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Abstract
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Salsola collina (S. collina) is an annual plant widely distributed in drought and semi-drought areas, which has been used for a long time as a kind of folk remedy in traditional Chinese medicine for the treatment of hypertension. Previously, the anti-oxidative and anti-cancer activities of S. collina were elucidated in our research group. In this study, the anti-obesity activities of S. collina ethanol extract (SCEE) were evaluated using a pancreatic lipase enzyme inhibition assay and cell culture model. The results showed that SCEE effectively suppressed pancreatic lipase enzyme activity in a dose-dependent manner. Furthermore, SCEE significantly suppressed adipocyte differentiation, lipid accumulation, and triglyceride (TG) content, and triggered lipolysis on insulin, dexamethasone, and 3-isobutyl-l-methylxanthine-treated 3T3-L1 preadipocytes in a dose-dependent manner without cytotoxicity. Its anti-obesity effect was modulated by cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ¥á (C/EBP¥á), C/EBP¥â, and the peroxisome proliferator-activated receptor ¥ã (PPAR¥ã) gene, as well as protein expressions. Taken together, these results offer the important new insight that S. collina possesses anti-obesity properties, such as pancreatic lipase inhibition and anti-adipogenic and lipolysis effects through the modulation of their upstream signaling pathway. It could become a promising source in the field of nutraceuticals, and the identification of active compounds that confer the biological activities of SCEE may be needed.
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KEYWORD
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Anti-adipogenic and lipolysis effects, anti-obesity activity, lipase inhibition activity, Salsola collina ethanol extract
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